Quantitative Study of Secretory Granules of the Parotid Gland Acinar Cell of the Rat

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Abstract
The number and size of secretory granules of rat parotid acinar cells were stereologically estimated and their size distribution was analyzed, furthermore the alterations of these data in the starred and isoproterenol (IPR) administered conditions were studied. The size frequency distribution of the granule was bimodal in general, with some exceptions in the control and starved group. The bimodal distribution was more obvious of the IPR injected groups. The numerical density of the whole granule decreased at six hours after IPR Injection as compared with that of the control, although the small granules increased. Both the small and large granules Increased at twelve hours after IPR injection as compared with those at six hours. These findings suggested that three stages, the formation of the small granules, the maturation to the large and the discharge, may be present in the secretory cycle of the parotid acinar cell.