Interleukin‐2 Increases CD4+Lymphocyte Numbers but Does Not Enhance Responses to Immunization: Results of A5046s

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Abstract
To ascertain whether CD4+ lymphocyte increases induced by interleukin (IL)–2 enhanced in vivo immune responses, 38 human immunodeficiency virus (HIV)–infected patients who had received highly active antiretroviral therapy (HAART) or HAART and IL-2 for at least 60 weeks were immunized with tetanus toxoid, inactivated glycoprotein 120–depleted HIV-1, and hepatitis A and B vaccines. Despite dramatic increases in CD4+ lymphocyte counts, IL-2 did not enhance immunization responses