Involvement of the Chemokine RANTES (CCL5) in Resistance to Experimental Infection with Leishmania major
Open Access
- 1 August 2004
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 72 (8) , 4918-4923
- https://doi.org/10.1128/iai.72.8.4918-4923.2004
Abstract
The expression and putative role of chemokines during infection with Leishmania major in mice were investigated. CCL5 expression correlates with resistance, and blockade of CCL5 rendered mice more susceptible to infection. CCL5 is part of the cascade of events leading to efficient parasite control in L. major infection.Keywords
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