REGIONAL DIFFERENCES IN INCIDENCE AND GROWTH OF MOUSE TUMORS FOLLOWING INTRADERMAL OR SUBCUTANEOUS INOCULATION

  • 1 January 1978
    • journal article
    • research article
    • Vol. 38  (6) , 1739-1744
Abstract
Tumor cells inoculated intradermally or s.c. into more cranial regions of the lateral trunk show strikingly greater tumor growth and development than similar cells injected more caudally. At low tumor cell doses the incidence anteriorly may be double that found posteriorly and tumors become detectable more rapidly anteriorly; at higher cell doses the anterior:posterior ratio of tumor weight may be 4:1. The effect appears to be independent of the type of tumor used (mastocytoma, sarcoma, teratoma, lymphoma or adenocarcinoma) and the strain of mouse host. It does not appear to be influenced by the sex of the host animal, immunogenicity of the tumor or immunological competence of the tumor recipient. The results are discussed in terms of practical considerations for developing adequate tumor transplantation and treatment protocols and in terms of the biological significance in relation to spontaneous or induced oncogenesis.

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