A heat‐generating bioactive glass–ceramic for hyperthermia

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Abstract
Glass plates of the chemical composition: CaO (29.0), SiO2 (31.0), Fe2O3 (40.0), B2O3 (3.0), P2O5 (3.0) in weight ratio were heated to 1050 °C at a rate of 5 °C/min and then cooled to laboratory temperature. The resulting glass–ceramic containing magnetite and wollastonite crystals showed high-saturation magnetization. The bonding ability of this new glass–ceramic to bone tissue was evaluated using rabbit tibiae, and compared with glass of the same composition. This glass–ceramic formed a Ca, P-rich layer on its surface and bonded tightly with bone within 8 weeks of implantation. However, the glass did not form this Ca, P-rich layer, nor had it bonded with bone at 25 weeks. The bone-heating ability of this glass–ceramic was investigated by applying a max. 300-Oe, 100-kHz magnetic field. The granules of the glass–ceramic filled in the rabbit tibiae heated the whole surrounding bone to more than 42 °C and maintained this temperature for 30 min. Bioactive ceramics reinforce the mechanical strength of bone tissue. Furthermore, this heat-generating bioactive glass–ceramic can be used for hyperthermic treatment of bone tumors.

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