A prospective study of Plasmodium falciparum multiplicity of infection and morbidity in Tanzanian children
- 1 December 2004
- journal article
- Published by Oxford University Press (OUP) in Transactions of the Royal Society of Tropical Medicine and Hygiene
- Vol. 98 (12) , 687-694
- https://doi.org/10.1016/j.trstmh.2004.03.010
Abstract
We studied the viability of Plasmodium falciparum parasites reappearing in long-term cultures after repetitive exposure to atovaquone and proguanil. Parasites (F32 and FCR3) exposed to 100–5000 nM atovaquone for 96 hours were reduced to cytb), associated with atovaquone resistance, were detected in any recrudescing parasites. Finally, parasites (F32) exposed to various concentrations of atovaquone and proguanil in combination for 72 hours reappeared after 9–17 days. The baseline susceptibilities of the parasites to individual drugs were similar before and after recrudescence in all experiments.Keywords
This publication has 27 references indexed in Scilit:
- An estimation of the entomological inoculation rate for Ifakara: a semi‐urban area in a region of intense malaria transmission in TanzaniaTropical Medicine & International Health, 2003
- Plasmodium falciparumGenotypes, Low Complexity of Infection, and Resistance to Subsequent Malaria in Participants in the Asembo Bay Cohort ProjectInfection and Immunity, 2001
- 8. Effect of iron supplementation and malaria prophylaxis in infants on Plasmodium falciparum genotypes and multiplicity of infectionTransactions of the Royal Society of Tropical Medicine and Hygiene, 1999
- Clone multiplicity of Plasmodium falciparum infections in individuals exposed to variable levels of disease transmissionTransactions of the Royal Society of Tropical Medicine and Hygiene, 1998
- Incidence of Plasmodium falciparum infection in infants in relation to exposure to sporozoite-infected anophelines.The American Journal of Tropical Medicine and Hygiene, 1998
- Reduced risk of clinical malaria in children infected with multiple clones of Plasmodium falciparum in a highly endemic area: a prospective community studyTransactions of the Royal Society of Tropical Medicine and Hygiene, 1997
- Analysis of MultiplePlasmodium falciparumInfections in Tanzanian Children during the Phase III Trial of the Malaria Vaccine SPf66The Journal of Infectious Diseases, 1997
- Humoral Response to Defined Plasmodium falciparum Antigens in Cerebral and Uncomplicated Malaria and their Relationship to Parasite GenotypeThe American Journal of Tropical Medicine and Hygiene, 1997
- Different Genetic Characteristics of Plasmodium falciparum Isolates Collected During Successive Clinical Malaria Episodes in Senegalese ChildrenThe American Journal of Tropical Medicine and Hygiene, 1996
- Randomised trial of efficacy of SPf66 vaccine against Plasmodium falciparum malaria in children in southern TanzaniaThe Lancet, 1994