Studies on the hydrolysis of clavulanic acid
- 1 January 1984
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 6,p. 1345-1349
- https://doi.org/10.1039/p19840001345
Abstract
1-Amino-4-hydroxybutan-2-one (14) has been identified as one of the major products from the hydrolysis of clavulanic acid in acidic, alkaline, or neutral solution. In alkaline or neutral solution, the amino ketone (14) is converted into other products, including two pyrazines, 2,5-bis(2-hydroxyethyl)pyrazine and 3-ethyl-2,5-bis(2-hydroxyethyl)pyrazine. A rationale for the formation of these products is discussed.This publication has 2 references indexed in Scilit:
- Nuclear modification of clavulanic acid. The preparation of two 4,7-fused β-lactam systemsJournal of the Chemical Society, Perkin Transactions 1, 1983
- Structure, reactivity, and biological activity of strained bicyclic .beta.-lactamsJournal of the American Chemical Society, 1981