Prognostication of astrocytoma patient survival by Ki‐67 (MIB‐1), PCNA, and S‐phase fraction using archival paraffin‐embedded samples

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Abstract
The prognostic power of three proliferation estimation methods, Ki‐67 (MIB‐1) and PCNA immunohistochemistry, and flow cytometry (S‐phase and S+G2/M fractions, respectively), were evaluated in 50 cases of astrocytoma. Each proliferation index showed a strong association with the grade of malignancy (grades I‐IV). The MIB‐1 labelling index (LI) provided additional information, as it could be used for the discrimination of grade II and grade III astrocytomas (P=0·0357). All three proliferation estimation methods also had strong prognostic potential (MIB‐1 LI: PP15·3 per cent) were alive after 2‐years' follow‐up. In contrast, 72 per cent of patients with tumours of low proliferation activity survived. It appears that Ki‐67 (MIB‐1) immunolabelling using archival paraffin‐embedded samples is of value in predicting prognosis in astrocytic tumours.