Effect of certain thyroxine analogues on liver cholesterol

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Abstract
L-Thyroxine, l-triiodothyronine, their d-isomers, and their formic, acetic, propionic and butyric acid analogues were given to cholesterol-thiouracil-fed rats and the effect on thyroid weight and serum and liver cholesterol determined. l-Thyroxine, d-thyroxine and tetraiodothyroformic acid were also given to cholesterol-fed rats and the effect on oxygen use and serum and liver cholesterol measured. The substitution of either d-alanine or a carboxyl group for the l-alanine side chain of thyroxine and triiodothyronine resulted in a degree of dissociation of goiter-inhibiting and liver cholesterol effects. Thus, these substituted compounds at doses having equal or less goiter-inhibiting effects resulted in significantly lower liver cholesterol levels than did l-thyroxine or l-triiodothyronine. The effect of d-thyroxine and tetraiodothyroformic acid on liver cholesterol was also disproportionate to their calorigenic activity as compared to l-thyroxine.