MECHANISM OF SERUM CHOLESTEROL-LOWERING ACTION OF AN ANABOLIC STEROID IN CONTRAST TO A GLUCORTICOID

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Abstract
Mechanisms of the hypocholesteremic action of an anabolic steroid, 2-hydroxymethylene-17-methyl- dihydrotestosterone (HMD) were investigated in contrast to the hypercholesteremic effect of a glucocorticoid cortisone. HMD or cortisone increased the in vivo incorporation of acetate-1-14C into rat liver cholesterol 15 min. after 14C injection and decreased the incorporation 4 hr after 14C injection. Almost the same results were observed in the intestine. Biliary excretion of total 14C and bile acids- 14C after cholesterol-4-14C injection was increased by HMD and slightly decreased by cortisone. The gastrointestinal absorption of cholesterol-4-14C or cholic acid-4-14C was accelerated by cortisone, while almost no effect was observed with HMD.