Effect of recombinant human interleukin-6 on nitrite production of mouse myeloid leukemia cells
- 1 May 1991
- journal article
- research article
- Published by Wiley in Journal of Cellular Physiology
- Vol. 147 (2) , 306-310
- https://doi.org/10.1002/jcp.1041470216
Abstract
The effect of recombinant human interleukin‐6 (rhlL‐6) on induction of nitrite (NO ) production was investigated in a mouse myeloid leukemia cell line (M1) and a subclone (Mm1). NO was induced by rhlL‐6 (>50 U/ml) in these cell lines. Pretreatment with rhlL‐6 (100 U/ml) for 1 day synergistically enhanced the production of NO in Mm1 by LPS. Furthermore, pretreatment withl lL‐6 (100 U/ml) shortened the lag time of induction. These results indicate that lL‐6 is involved in the regulation of the NO production in macrophage‐like cells.Keywords
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