Urinary Hemoglobin Excretion and Renal Circulatory Dynamics: A Study of the Effect of L-Norepinephrine in the Dog 12

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Abstract
The administration of pressor doses of l-norepinephrine to anesthestized dogs increased abruptly the urinary excretion and renal clearance of hemoglobin when this protein was infused intravenously at a rate sufficient to maintain plasma levels above the renal threshold. This change in clearance appeared to result from an increase in trans-glomerular transport of hemoglobin molecules, the mechanism of which was not established. This increase in transport may have been caused by a more prolonged contact between hemoglobin molecules and the glomerular membrane as a result of the slowing of blood flow through the glomerulus.