Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter
Top Cited Papers
- 12 December 2004
- journal article
- research article
- Published by Springer Nature in Nature Neuroscience
- Vol. 8 (1) , 20-21
- https://doi.org/10.1038/nn1366
Abstract
Major depression is conditionally linked to a polymorphism of the human serotonin transporter gene (SLC6A4). During the presentation of aversive, but not pleasant, pictures, healthy carriers of the SLC6A4 short (s) allele showed stronger activation of the amygdala on functional magnetic resonance imaging. s carriers also showed greater coupling between the amygdala and the ventromedial prefrontal cortex, which may contribute to the abnormally high activity in the amygdala and medial prefrontal cortex seen in major depression.Keywords
This publication has 13 references indexed in Scilit:
- Prefrontal Cortex Projections to the Rat AmygdalaAnnals of the New York Academy of Sciences, 2006
- Amygdalar interhemispheric functional connectivity differs between the non-depressed and depressed human brainNeuroImage, 2004
- Common and distinct neural responses during direct and incidental processing of multiple facial emotionsNeuroImage, 2003
- Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT GeneScience, 2003
- Serotonin Transporter Genetic Variation and the Response of the Human AmygdalaScience, 2002
- Human fear conditioning is related to dopaminergic and serotonergic biological markers.Behavioral Neuroscience, 2001
- Psychophysiological and Modulatory Interactions in NeuroimagingNeuroImage, 1997
- Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory RegionScience, 1996
- Measuring emotion: The self-assessment manikin and the semantic differentialJournal of Behavior Therapy and Experimental Psychiatry, 1994
- Amygdalo‐cortical projections in the monkey (Macaca fascicularis)Journal of Comparative Neurology, 1984