Clinical response to therapy with thymopoietin pentapeptide (TP-5) in rheumatoid arthritis
Open Access
- 1 October 1982
- journal article
- research article
- Published by Elsevier in Annals of the Rheumatic Diseases
- Vol. 41 (5) , 441-443
- https://doi.org/10.1136/ard.41.5.441
Abstract
The effect of thymopoietin pentapeptide (TP-5) was evaluated in patients with rheumatoid arthritis (RA). Ninety-two patients were divided into 3 groups, namely, placebo, TP-5 intramuscularly (IM) 1 mg, TP-5 intravenously (IV) 50 mg, and were evaluated for 6 measures of disease activity at the beginning of the study and at 3 and 6 months. No difference was observed between the placebo group and the group treated with TP-5 IM 1 mg. However, in the group treated with TP-5 IV 50 mg a statistically significant improvement of all parameters except the ESR was observed.This publication has 10 references indexed in Scilit:
- Immunopathogenesis of rheumatoid arthritisThe American Journal of Medicine, 1979
- SHORT IN VITRO HALF‐LIFE OF THYMOPOIETIN 32–36 PENTAPEPTIDE IN HUMAN PLASMAInternational Journal of Peptide and Protein Research, 1979
- A Synthetic Pentapeptide with Biological Activity Characteristic of the Thymic Hormone ThymopoietinScience, 1979
- The generation and regulation of lymphocyte populations: evidence from differentiative induction systems in vitro.The Journal of Experimental Medicine, 1978
- Levamisole in rheumatoid arthritis--a multivariate analysis of a multicentric study.1978
- MEASUREMENT OF PAINPublished by Elsevier ,1974
- Comparison of Azathioprine, Cyclophosphamide, and Gold in Treatment of Rheumatoid ArthritisBMJ, 1974
- Induction of T-Cell Differentiation In Vitro by Thymin, a Purified Polypeptide Hormone of the ThymusProceedings of the National Academy of Sciences, 1974
- Isolation of Bovine Thymin: a Polypeptide Hormone of the ThymusNature, 1974
- Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis.1968