Screening for Apoptosis Inducers in Microbial Products and Induction of Apoptosis by Cytostatin.
- 1 January 1995
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 48 (10) , 1138-1140
- https://doi.org/10.7164/antibiotics.48.1138
Abstract
We have employed the DNA-methylgreen binding assay as a primary screening method for identifying apoptosis inducers in microbial products. Capsimycin, toyocamycin and cytostatin affect the binding of methylgreen to DNA of FS3 cells in this test system. The effect of cytostatin on apoptosis induction was confirmed by means of the ELISA system.Keywords
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