Damage to DNA induces expression of the ruv gene of Escherichia coli
- 1 April 1982
- journal article
- research article
- Published by Springer Nature in Molecular Genetics and Genomics
- Vol. 185 (2) , 352-355
- https://doi.org/10.1007/bf00330811
Abstract
Summary Regulation of the ruv gene of E. coli was studied using phage Mud (Ap lac) to obtain a fusion of the lac genes to the ruv promoter. β-galactosidase synthesis in the ruv-lac fusion strain was induced by mitomycin C and other agents that damage DNA. The induction of β-galactosidase could be altered by mutations either in lexA or recA from which it is concluded that ruv is regulated by lexA repressor. A possible function of ruv in promoting cell recovery following damage to DNA is discussed.Keywords
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