INFLUENCE OF VARIOUS STEROIDS ON THE OXIDATIVE FUNCTION OF RAT TISSUE PREPARATIONS1

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Abstract
This study was undertaken to ascertain what influence steroid hormones may have on tissue respiration, and secondly, if any effect could be demonstrated, which specific enzymes were involved. Early in the course of our work Gordon and Elliot (1947) reported that testosterone and other steroids depressed the in vitro aerobic respiration of rat brain in the presence of glucose. More recently Eisenberg, Gordon, and Elliot (1949) have reported that testosterone suspensions inhibit the oxygen uptake of rat brain, liver, and striated muscle slices. Our studies confirm and extend these studies. In this communication data on the inhibitory action of various steroids on oxygen uptake of liver, kidney, and brain preparations are presented, while another paper (Hayano and Dorfman, 1950) deals specifically with the inhibition of the D-amino acid oxidase system by desoxycorticosterone. Slices.—Livers, kidneys, and brains of adult male albino rats (100–200 g.) were removed shortly after the animals had been decapitated and bled.