Neutralizing monoclonal antibody against ras oncogene product p21 which impairs guanine nucleotide exchange.
Open Access
- 1 May 1987
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 7 (5) , 1999-2002
- https://doi.org/10.1128/mcb.7.5.1999
Abstract
The neutralizing monoclonal antibody Y13-259 severely hampers the nucleotide exchange reaction between p21-bound and exogenous guanine nucleotides but does not interfere with the association of GDP to p21. These results suggest that the nucleotide exchange reaction is critical for p21 function. Interestingly, the v-ras p21 has a much faster dissociation rate than the p21 of the c-ras proto-oncogene.This publication has 27 references indexed in Scilit:
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