Column-Switching High-Performance Liquid Chromatography for On-Line Simultaneous Determination and Resolution of Enantiomers of Verapamil and Its Metabolites in Plasma
- 1 January 1991
- journal article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 08 (8) , 997-1001
- https://doi.org/10.1023/a:1015848806240
Abstract
An on-line simultaneous assay for the enantiomers of verapamil (VA) and its three metabolites in plasma was developed with column-switching HPLC. This system consists of an ovomucoid protein chiral...Keywords
This publication has 20 references indexed in Scilit:
- Direct resolution of the stereoisomers of leucovorin and 5-methyltetrahydrofolate using a bovine serum albumin high-performance liquid chromatographic chiral stationary phase coupled to an achiral phenyl columnJournal of Chromatography B: Biomedical Sciences and Applications, 1988
- Separation of Drug Stereoisomers by the Formation of β-Cyclodextrin Inclusion ComplexesScience, 1986
- Simultaneous quantitation of verapamil, norverapamil, and n-dealkylated metabolites in human plasma following oral administrationJournal of Chromatography B: Biomedical Sciences and Applications, 1985
- Effects of d,l-verapamil on atrioventricular conduction in relation to its stereoselective first-pass metabolismClinical Pharmacology & Therapeutics, 1985
- The effect of dextro-, levo-, and racemic verapamil on atrioventricular conduction in humansAmerican Heart Journal, 1985
- Pharmacokinetics of (+)‐, (‐)‐ and (+/‐)‐verapamil after intravenous administration.British Journal of Clinical Pharmacology, 1984
- Rapid high-performance liquid chromatographic method for the measurement of verapamil and norverapamil in blood plasma or serumJournal of Chromatography A, 1981
- Simultaneous determination of verapamil and its seven metabolites by high-performance liquid chromatographyJournal of Chromatography B: Biomedical Sciences and Applications, 1981
- Therapeutic implications of slow-channel blockade in cardiocirculatory disorders.Circulation, 1980
- Immediate Effects of Intravenous Verapamil in Cardiac ArrhythmiasBMJ, 1972