Pumped Biochemical Reactions, Nonequilibrium Circulation, and Stochastic Resonance

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Abstract
Based on a master equation formalism for mesoscopic, unimolecular biochemical reactions, we show the periodic oscillation arising from severe nonequilibrium pumping is intimately related to the periodic motion in recently studied stochastic resonance (SR). The white noise in SR is naturally identified with the temperature in the biochemical reactions; the drift in the SR is associated with the circular flux in nonequilibrium steady state (NESS). As in SR, an optimal temperature for biochemical oscillation is shown to exist. A unifying framework for Hill's theory of NESS and the SR without periodic forcing is presented. The new formalism provides an analytically solvable model for SR.