High Levels of Dopamine Activity in the Basal Ganglia of Cigarette Smokers
- 1 April 2000
- journal article
- Published by American Psychiatric Association Publishing in American Journal of Psychiatry
- Vol. 157 (4) , 632-634
- https://doi.org/10.1176/appi.ajp.157.4.632
Abstract
The authors' goal was to study presynaptic dopamine activity in smoking and nonsmoking human subjects in vivo. [(18)F]Fluorodopa ([(18)F]DOPA) uptake K(i) values in the basal ganglia of nine smoking and 10 nonsmoking healthy men were measured with positron emission tomography. Significantly higher [(18)F]DOPA uptake was observed in both the putamen (average 17.3% higher) and the caudate (average 30.4% higher) of smokers than in those of nonsmokers. Smoking is related to greater dopamine activity in the human basal ganglia. Nicotine-induced dopamine activity may be a relevant mechanism in dependence on cigarette smoking.Keywords
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