SYNTHESIS OF GAMMA-L-GLUTAMYL-TAURINE

  • 1 January 1980
    • journal article
    • research article
    • Vol. 16  (4) , 245-247
Abstract
Glu(Tau), a bioactive substance previously isolated from the protein free aqueous extract of bovine parathyroid powder, was synthesized. The intermediate derivative Z[benzyloxycarbonyl]-Glu(Tau)-OBzl was prepared in 3 different ways from Z-Glu-OBzl and cystamine by using the mixed anhydride method followed by oxidation, Tau by the active ester procedure via Z-Glu(ONp)-OBzl and Tau applying mixed anhydride coupling. The protecting groups were removed by hydrogenolysis.

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