LEUKEMOID REACTION INDUCED BY DIFFERENT TRANSPLANTABLE TUMORS IN 3 INBRED MOUSE STRAINS

  • 1 January 1982
    • journal article
    • research article
    • Vol. 29  (1) , 73-79
Abstract
The induction of a granulocyte-associated leukocytosis (leukemoid reaction) in C3HA, C57Bl/6 and DBA/2 mice by a number of transplantable tumors of different origins was studied. Leukemia L1210, Hepatoma 22, a transplantable mammary carcinoma of spontaneous C3HA origin and a L929 culture fibroblast-derived rhabdomyosarcoma all induced a leukemoid reaction in their specific mouse strain. Melanoma B16 and Lewis lung carcinoma gave no reaction. Adenocarcinoma 755 and Harding-Passey melanoma evoked a leukocytosis but not due to an increase in neutrophils. Some extratumoral factors can influence the hematological response: the intensity of final leukemoid reaction was higher in female mice than in males bearing the same tumor. Ehrlich ascites tumor transplanted in all 3 inbred mouse strains rendered different levels of leukemoid reaction; the response was higher in DBA/2, intermediate in C3HA and lower in C57Bl/6.