Intravenous nitroglycerin for the treatment of chronic cerebral vasoconstriction in the primate

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Abstract
A primate model of chronic cerebral vasoconstriction is presented which consistently produced SAH [subarachnoid hemorrhage] followed in 5 days by constriction of the vessels adjacent to the site of the hemorrhage, and accompanied by a neurological deficit. An i.v. method of nitroglycerin delivery was used and a modest, but statistically significant increase in the size of constricted vessels was seen. Results were compared with a similar experiment using a canine model and a marked difference in results was seen. Caution is recommended when extrapolating results to humans.