EFFECTS OF BUPROPION ON BODY-WEIGHT

  • 1 January 1983
    • journal article
    • research article
    • Vol. 44  (5) , 183-186
Abstract
Patients'' weights were assessed during placebo-controlled, amitriptyline-controlled and uncontrolled bupropion trials. Low-moderate (50-450 mg/day) to moderate-high (300-750 mg/day) doses of bupropion were consistently associated with a lack of weight gain (average weight loss of 1-2 lb); placebo was associated with an average weight gain of 1 lb and 75-225 mg/day of amitriptyline was associated with an increase of 3-9 lb. Bupropion treatment was rarely accompanied by reports of appetite change and had no statistically significant effect on caloric intake when compared to placebo.

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