A Quantitative Study of Water Diffusion in Multiple Sclerosis Lesions and Normal-Appearing White Matter Using Echo-Planar Imaging

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Abstract
IN MULTIPLE SCLEROSIS (MS), conventional magnetic resonance imaging (MRI) has proved to be sensitive in detecting lesions and their changes over time.1,2 However, conventional MRI is not without relevant limitations. These include the lack of specificity to the heterogeneous pathologic substrates of MS lesions3-5 and the inability to detect subtle abnormalities in the so-called normal-appearing white matter (NAWM).5