Possible Release of an ArgGlyArgProGln Pentapeptide with Innate Immunity Properties from Acidic Proline-Rich Proteins by Proteolytic Activity in Commensal Streptococcus and Actinomyces Species
Open Access
- 1 September 2000
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 68 (9) , 5425-5429
- https://doi.org/10.1128/iai.68.9.5425-5429.2000
Abstract
This study suggests degradation of salivary acidic proline-rich proteins (PRPs) into potential innate-immunity-like peptides by oralStreptococcus and Actinomyces species. PRP degradation paralleled cleavage of Pro-containing substrates. PRP degradation by S. gordonii strain SK12 instantly released a Pyr1-Pro104Pro105 and a Gly111-Pro149Gln150 peptide together with a presumed Arg106Gly107Arg108Pro109Gln110pentapeptide. The synthetic Arg106Gly107Arg108Pro109Gln110peptide desorbed bound bacteria and counteracted sucrose-induced decrease of dental plaque pH in vitro.Keywords
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