Stress, NK Receptors, and Immune Surveillance
- 19 October 2001
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 294 (5542) , 534-536
- https://doi.org/10.1126/science.1066284
Abstract
It has long been suspected that natural killer (NK) cells are involved in immune surveillance. Now comes new work, described by Pardoll in his Perspective, showing that gd T cells expressing an NK cell receptor called NKG2d are important for detecting precancerous skin epithelial cells in mice ( Girardi et al.). Engagement of NKG2d with its ligands Rae-1 or H60 expressed on mouse epidermal cells treated with carcinogens results in activation of gd T cells, which eliminate the precancerous epidermal cells before they become established as tumors.Keywords
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