Association Between Hypermethylated Tumor and Paired Surgical Margins in Head and Neck Squamous Cell Carcinomas
Open Access
- 1 September 2007
- journal article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 13 (17) , 5089-5094
- https://doi.org/10.1158/1078-0432.ccr-07-0119
Abstract
Purpose: Surgical margin status is reported to be a relevant prognostic factor in head and neck squamous cell carcinoma (HNSCC), associated with a high risk of local recurrence. This study examines whether gene-promoter hypermethylation could be detected in HNSCC surgical margins with no histologic evidence of malignancy, and if so, whether it reflects epigenetic events of primary tumors.Keywords
This publication has 33 references indexed in Scilit:
- Aberrant promoter hypermethylation of p16 and MGMT genes in oral squamous cell carcinomas and the surrounding normal mucosaZeitschrift für Krebsforschung und Klinische Onkologie, 2006
- Gene Promoter Methylation in Prostate Tumor–Associated Stromal CellsJNCI Journal of the National Cancer Institute, 2006
- Postoperative irradiation for squamous cell carcinoma of the oral cavity: 35‐year experienceHead & Neck, 2004
- Promoter Hypermethylation of Resected Bronchial MarginsClinical Cancer Research, 2004
- Epigenetics in human disease and prospects for epigenetic therapyNature, 2004
- Gene promoter hypermethylation in oral rinses of leukoplakia patients—a diagnostic and/or prognostic tool?European Journal Of Cancer, 2003
- The study of p16 and p15 gene methylation in head and neck squamous cell carcinoma and their quantitative evaluation in plasma by real-time PCREuropean Journal Of Cancer, 2003
- Aberrant p16 promoter methylation in smokers and former smokers with nonsmall cell lung cancerInternational Journal of Cancer, 2003
- Multiple oral squamous epithelial lesions: are they genetically related?Oncogene, 2001
- Surgical Excision MarginsAdvances in Anatomic Pathology, 1999