Mono-oxygenase activities of coho salmon (Oncorhynchus kisutch) liver microsomes using three polycyclic aromatic hydrocarbon substrates
- 1 January 1980
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 10 (3) , 229-234
- https://doi.org/10.3109/00498258009033749
Abstract
1. Benzo[a]pyrene, 2,6-dimethylnaphthalene, and naphthalene were used as substrates for a coho salmon (Oncorhynchus kisutch) liver microsomal preparation. 2. The apparent Michaelis constants (Km) were as follows: benzo[a]pyrene, 2.1 μM; 2,6-dimethylnaphthalene, 15.3 μm; and naphthalene, 300 μM. 3. The results indicate that the microsomal preparation had a high affinity for 2,6-dimethylnaphthalene. Thus, 2,6-dimethylnaphthalene, an important constituent of petroleum products, is a useful substrate for research on the disposition in vivo and in vitro of xenobiotics introduced into marine environments by petroleum pollution.This publication has 30 references indexed in Scilit:
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