RELATIONSHIP BETWEEN SERUM AND BRAIN CONCENTRATIONS OF PHENYTOIN IN THE DOG

  • 1 January 1979
    • journal article
    • research article
    • Vol. 40  (4) , 473-476
Abstract
Phenytoin (DPH) is used in veterinary medicine to control seizures in the dog, but knowledge of its disposition in this species is incomplete. The concentration of phenytoin (DPH) in the CNS of adult dogs given the drug by i.v. injection, continuous i.v. infusion, or repeated daily oral administration and of newborn pups given DPH by i.v. injection were consistently proportional to serum drug concentrations at the time of blood sample collections. Adult dogs injected i.v. with [14C]DPH failed to show predilection of the drug for the 13 anatomic brain sections sampled. The pharmacokinetics of DPH were studied in adult and neonatal dogs given 15 mg of the drug/kg of body weight as a single i.v. injection. The mean half-life of the drug in adult dogs injected i.v. was 4.5 hours. The serum half-life of injected DPH was lowest in pups 30 days of age when compared with that in other age groups. The serum half-life of injected DPH was increased in adult dogs under pentobarbital anesthesia.

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