EFFECT OF FUROSEMIDE ON CANINE SPLENIC ARTERIAL BLOOD-FLOW

  • 1 January 1979
    • journal article
    • research article
    • Vol. 23  (3) , 627-630
Abstract
Furosemide reportedly causes pathological changes in the intestines as a consequence of the decreased splanchnic blood flow that it produces. In view of the pancreatic toxicities of this diuretic, the effect of the agent on blood flow to this organ was examined. An electromagnetic flow probe was placed around the splenic artery, a vessel which supplies a major fraction of pancreatic blood flow. Within 60 min after furosemide (1 mg/kg, i.v.) administration, splenic blood flow (SBF) decreased by 20% and the decrease paralleled the drug-induced diuresis. When diuresis was prevented, the agent failed to affect SBF. Furosemide causes a reduction in SBF, which appears to involve a mechanism dependent upon the volume reduction produced by the drug-induced diuresis.

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