Platelet HLA Typing and Cross‐Matching by a Direct Microcytotoxic Assay

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Abstract
Carboxyfluoresceindiacetate-labeled platelets can be used in direct microcytotoxic assays for typing platelets for a number of antigenic determinants, such as HLA and .beta.-2 microglobulin. The assay when used in direct platelet cross-matching, where thrombocytopenic patient sera were screened, resulted in the uncovering of many extrapositive and weakly positive cross-matches not identified by the lymphocyte cross-match. The simplicity and rapidity of this new method makes it an attractive alternative for future use in research and clinical studies.