Human Laboratory Infection with Venezuelan Equine Encephalomyelitis Virus

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Abstract
THE occurrence of human cases of encephalomyelitis due to laboratory infection with Venezuelan equine encephalomyelitis virus was reported for the first time by Casals et al.1 and by Lennette and Koprowski2 in 1943. The course of the disease described by these authors varied from patient to patient; mild, almost ambulatory cases paralleled severer ones in which involvement of the central nervous system was manifest.Two fatal cases with subsequent isolation of Venezuelan equine virus from the brain tissue were subsequently recorded.3 , 4 One of these cases preceded3 whereas the other occurred during4 an epizootic caused by the same virus among horses . . .