VARIABILITY OF ANTI-GBM BINDING IN HEREDITARY NEPHRITIS

  • 1 January 1981
    • journal article
    • research article
    • Vol. 15  (3) , 111-114
Abstract
Anti-GBM [glomerular basement membrane] staining by indirect immunofluorescence microscopy was performed on renal biopsies from 64 patients with a variety of diseases in which no in vivo bound Ig or complement components were identified by direct immunofluorescence microscopy. The glomeruli of all of the entities examined bound anti-GBM antibodies except for 4 of 9 cases of hereditary nephritis of the Alport-type. The absence of anti-GBM staining correlated with the severity of GBM splitting identified by EM.

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