Metabolic Clearance and Plasma Half Disappearance Time of Exogenous Gonadotropin Releasing Hormone in Normal Subjects and in Patients with Liver Disease and Chronic Renal Failure

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Abstract
The metabolic clearance rate (MCR) and half disappearance time (T1/2) of gonadotropin releasing hormone (G nRH) has been measured during and after cessation of constant infusion of exogenous G nRH. Studies were performed on normal subjects and patients with severe renal and liver disease. G nRH was quantified by a sensitive and specific radioimmunoassay which does not measure G nRH fragments. The MCR of G nRH in normal subjects was 1640 ± 59.7 ml/min (23.7 ± 1.8 ml/min/ kg), similar to values found in 4 patients with liver disease. However in chronic renal failure an MCR of only 631 ± 62 ml/min (9.1 ± 0.7 ml/min/kg) was obtained. The T1/2 of G nRH after infusion was linear for 8–10 min, after which a much slower component was observed. The T1/2 of the first component ranged from 5.5 to 8 min in normal subjects, 6.5–8 min in patients with liver disease but was prolonged (12–16.5 min) in patients with renal failure. It would appear that G nRH is cleared rapidly in normal subjects, that moderate liver dysfunction does not alter this, but that impaired renal function significantly prolongs the T1/2 and lowers the MCR. The kidney might be an important catabolic organ for infused G nRH; alternatively, uremia might impair catabolism nonspecifically.

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