Leukotriene receptors in atherosclerosis
- 1 January 2006
- journal article
- review article
- Published by Taylor & Francis in Annals of Medicine
- Vol. 38 (7) , 493-502
- https://doi.org/10.1080/07853890600982737
Abstract
Leukotriene-forming enzymes are expressed within atherosclerotic lesions and locally produced leukotrienes exert pro-inflammatory actions within the vascular wall by means of cell surface receptors of the BLT and CysLT receptor subtypes. The migration and accumulation of inflammatory cells that follow leukotriene receptor activation have been implicated in atherosclerosis initiation and progression. Leukotriene receptors are in addition expressed on endothelial and vascular smooth muscle cells, associated with intimal hyperplasia in early atherosclerosis and restenotic lesions after angioplasty. Taken together, recent evidence suggests that leukotriene receptors may be a potential target in the treatment of atherosclerosis and in the prevention of restenosis after coronary interventions.Keywords
This publication has 93 references indexed in Scilit:
- Complex Inheritance of the 5-Lipoxygenase Locus Influencing Atherosclerosis in MiceGenetics, 2006
- Expression of 5-lipoxygenase and leukotriene A 4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instabilityProceedings of the National Academy of Sciences, 2006
- Differential induction of BLT receptor expression on human endothelial cells by lipopolysacharide, cytokines, and leukotriene B4Proceedings of the National Academy of Sciences, 2006
- Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cellsProceedings of the National Academy of Sciences, 2006
- Treatment of asthma with antileukotrienes: First line or last resort therapy?European Journal of Pharmacology, 2006
- Inflammation, Atherosclerosis, and Coronary Artery DiseaseNew England Journal of Medicine, 2005
- Functional Characterization of Cysteinyl Leukotriene CysLT2 Receptor on Human Coronary Artery Smooth Muscle CellsBiochemical and Biophysical Research Communications, 2001
- Cloning and Characterization of cDNA Encoding a Novel Human Leukotriene B4 ReceptorBiochemical and Biophysical Research Communications, 2000
- Regulation of Intracellular Calcium Release Channel Function by Arachidonic Acid and Leukotriene B4Biochemical and Biophysical Research Communications, 1997
- Leukotriene B4 induced hyperadhesiveness of endothelial cells for neutrophilsBiochemical and Biophysical Research Communications, 1990