THE EFFECTS OF LYSERGIC ACID DIETHYLAMIDE (LSD-25) UPON THE HISTOCHEMICAL REACTIONS FOR CHOLINESTERASE IN THE CENTRAL NERVOUS SYSTEM

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Abstract
Localization of inhibition of cholinesterases by lysergic acid diethylamide, a psycho-mimetic drug, was studied in rat brain. Gerebtzoff''s modification of Koelle''s method for histochemical demonstration of cholinesterases was used. Acetyl choline was used as a substrate for specific cholinesterase; butyrul choline as a substrate for non-specific cholinesterase. Non-specific cholinesterase activity was found in the capillary endothelium some glial cells and smooth muscle of arterioles. The specific esterase was found to have different degrees of intensity depending on the region of the brain with which it was associated. Types of localization were found to be associated with different layers of the cerebral cortex; varying degrees of intensity of intercellular reaction are found in different layers as well. LSD inhibition of non-specific cholinesterase was not observed; inhibition of specific cholinesterase was found to occur only in the cerebral cortex and was most marked in the lamina ganglionaris.

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