The Synthesis of Trisubstituted Enol Ethers and of Methyl Ketones from Ketones
- 15 March 1973
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 51 (6) , 981-983
- https://doi.org/10.1139/v73-145
Abstract
A reliable method for the synthesis of trisubstituted enol ethers (and of the corresponding methyl ketones) is described involving the condensation of the α-lithiated 2-methoxypropionic acid salt with a ketone to give a β-hydroxy acid, the cyclization to a β-lactone which is then decarboxylated (and mild acid hydrolysis of the enol ether).Keywords
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