Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma
Top Cited Papers
- 17 September 2009
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 361 (12) , 1164-1172
- https://doi.org/10.1056/nejmoa0905360
Abstract
Mutations in hedgehog pathway genes, primarily genes encoding patched homologue 1 (PTCH1) and smoothened homologue (SMO), occur in basal-cell carcinoma. In a phase 1 clinical trial, we assessed the safety and pharmacokinetics of GDC-0449, a small-molecule inhibitor of SMO, and responses of metastatic or locally advanced basal-cell carcinoma to the drug.Keywords
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