Synthesis of Isonucleosides Related to AZT and AZU
- 1 March 1994
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 13 (1-3) , 109-126
- https://doi.org/10.1080/15257779408013230
Abstract
Approaches to 1,4-anhydro-3-azido-2,3-dideoxy-2-[3,4-dihydro-2,4-dioxo-5-methyl-1(2 H)-pyrimidinyl]-D-arabinitol, and the related uracil derivative, have been developed. These conceptually new, optically active analogs of AZT, derived from 1,4-anhydro-D-ribitol, are among the first examples of regioisomeric analogs of AZT.Keywords
This publication has 35 references indexed in Scilit:
- Nucleosides LII1, Synthesis and Properties of Quinazoline-3′-azidonucleosidesNucleosides and Nucleotides, 1993
- REGIOSPECIFIC 5′-SILYLATION OF NUCLEOSIDESOrganic Preparations and Procedures International, 1990
- Synthesis and anti-HIV activity of various 2'- and 3'-substituted 2',3'-dideoxyadenosines: a structure-activity analysisJournal of Medicinal Chemistry, 1987
- The Toxicity of Azidothymidine (AZT) in the Treatment of Patients with AIDS and AIDS-Related ComplexNew England Journal of Medicine, 1987
- The Efficacy of Azidothymidine (AZT) in the Treatment of Patients with AIDS and AIDS-Related ComplexNew England Journal of Medicine, 1987
- Selective inhibition of human immunodeficiency virus (HIV) by 3′-Azido-2′,3′-dideoxyguanosine invitroBiochemical and Biophysical Research Communications, 1987
- The preparation of dioxaprostacyclin analogues fromD-(—)-riboseJournal of the Chemical Society, Perkin Transactions 1, 1983
- Isonucleosides. 2. Purine and pyrimidine derivatives of 1,4-anhydro-2-deoxy-D-arabinitolThe Journal of Organic Chemistry, 1978
- 32. Purines, pyrimidines, and glyoxalines. Part VII. New syntheses of 2-thiouracils and 2-thiothyminesJournal of the Chemical Society, 1958
- 861. Deoxynucleosides and related compounds. Part VIII. Some further transformations of O2: 2′-cyclouridineJournal of the Chemical Society, 1958