Regional cerebral blood flow in various types of brain tumor

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Abstract
Regional cerebral blood flow (rCBF) was measured in 23 patients with brain tumors by the 133Xe intracarotid injection method and a 254-channel .gamma.-camera. The glioblastomas (4) and astrocytomas (4) all showed hyperemia in the tumor and tumor-near region. This was also seen in several meningiomas (4 of 7 cases) in which most of the tumor itself did not receive any isotope. Brain metastases (6) usually had a low flow in the tumor and tumor-near region. The glioblastomas tended to show markedly bending 133Xe wash-out curves, pointing to pronounced heterogeneity of blood flow. Most of the flow maps, regardless of the tumor types, showed widespread abnormalities of rCBF in the tumor region and in the region remote from the tumor. Measurement of rCBF cannot yield accurate differential diagnostic information, but the widespread derangement of the brain issue function can be revealed even in the case of fairly small-size tumors.