Determination of Ranitidine in a Biological Material by Using Differential Pulse Adsorptive Stripping Voltammetry

Publisher Website
Google Scholar
Abstract
A method has been developed to determine Ranitidine in stomach tissue of patients treated with this drug by using differential pulse adsorptive stripping voltammetry. A hanging mercury drop electrode was chosen as the working electrode. Extraction of ranitidine from the stomach tissue has been accomplished by using liquid-liquid extraction with chloroform. A peak at -0.56 V vs Ag/AgCl at Britten-Robinson buffer pH 2.3 has been taken for calibration curve which has been found linear in between 5.26×10−10 M to 1.27×10−5 M. Its precision was estimated by 10 successive measurernents of 2×10−7 M ranitidine The relative standard deviation was 2.8 %. The percent recovery has been found as 81 %.