Prediction of 1-year survival after resection of lung tumours from the preoperative steroid excretion pattern

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Abstract
A prospective study of 50 patients with lung cancer who were treated by surgical resection of their tumour has shown that most of those who died within 1 year after resection had abnormalities in preoperative steroid excretion whereas most of those who are alive had normal steroid excretion. Of the 21 patients who died within 1 year, 5 died in hospital, mainly as a result of surgical complications, and were found to have an abnormally low androsterone to aetiocholanone ratio and a high total 17-oxosteroid excretion. Those who were discharged alive and well from hospital but who died within 1 year as a result of metastasis to other organs had a low androsterone level in relation to aetiocholanolone and to total 17-hydroxycorticosteroids. Thus, it has been possible to identify by their preoperative steroid excretion 12 out of 14 patients who died within 1 year although they had had a successful resection.