The urokinase plasminogen activator receptor in blood from healthy individuals and patients with cancer
- 1 March 1999
- Vol. 107 (1-6) , 160-167
- https://doi.org/10.1111/j.1699-0463.1999.tb01539.x
Abstract
The cell surface plasminogen activation system functions in promoting tumor dissemination, and is facilitated by a glycolipid anchored three domain receptor for urokinase. This receptor can also be found in a soluble form (suPAR) in extracts of tumors, as well as in plasma from both healthy individuals and cancer patients. The suPAR in plasma consists of the intact three domain protein, but neither the precise mechanism of its release from cell surfaces, nor its biological function are understood. Increased levels of plasma suPAR have been found in patients with cancers of the lung, breast, ovary, and colon, and recent data now indicates that the level of the molecule is related to patient prognosis.Keywords
This publication has 48 references indexed in Scilit:
- Structure, Function and Expression on Blood and Bone Marrow Cells of the Urokinase‐Type Plasminogen Activator Receptor, uPARThe International Journal of Cell Cloning, 1997
- Urokinase plasminogen activator, a strong independent prognostic factor in breast cancer, analysed in steroid receptor cytosols with a luminometric immunoassayEuropean Journal Of Cancer, 1996
- Urokinase plasminogen activator and urokinase plasminogen activator receptor in breast cancerInternational Journal of Cancer, 1995
- The receptor for urokinase plasminogen activator is present in plasma from healthy donors and elevated in patients with paroxysmal nocturnal haemoglobinuriaBritish Journal of Haematology, 1995
- Recombinant soluble urokinase receptor as a scavenger for urokinase‐type plasminogen activator (uPA)FEBS Letters, 1994
- Distribution and lateral mobility of the urokinase-receptor complex at the cell surface.Journal of Histochemistry & Cytochemistry, 1993
- Clinical Relevance of the Urokinase-Type and Tissue-Type Plasminogen Activators and of Their Type 1 Inhibitor in Breast CancerSeminars in Thrombosis and Hemostasis, 1991
- UROKINASE-TYPE PLASMINOGEN ACTIVATOR ANTIGEN AND EARLY RELAPSE IN BREAST CANCERThe Lancet, 1989
- Plasminogen Activator Released as Inactive Proenzyme from Murine Cells Transformed by Sarcoma VirusEuropean Journal of Biochemistry, 1982
- Endogenous Activation of Latent Collagenase by Rheumatoid Synovial CellsNew England Journal of Medicine, 1977