HEAVY-CHAIN VARIABLE REGION ALLOTYPIC SUBSPECIFICITIES OF RABBIT IMMUNOGLOBULINS .2. SELECTIVE ESCAPE OF THE A1-AB IG SUB-POPULATION AFTER THE INDUCTION OF AUTO ANTI-A1 ANTIBODY

  • 1 January 1979
    • journal article
    • research article
    • Vol. 122  (3) , 813-817
Abstract
An a1a2 rabbit (P286-3), neonatally suppressed for the expression of the a1 allotype, was immunized with autologous a1 Ig[immunoglobulin]G at 2 mo. of age. Auto anti-a1 Ab [antibody] and a1 IgG molecules were found in the serum of this rabbit after the auto-immunization. The auto anti-a1 Ab and the IgG from the auto anti-a1 Ab-depleted serum were isolated. Of the previously defined a1-AB, a1-AC and a1-AD Ig subpopulations, the a1 IgG in the IgG preparations from rabbit P286-3 were all of the a1-AB Ig subpopulation. The auto anti-a1 Ab from rabbit P286-3 did not react with the a1-A, a1-B and a1-C allotypic subspecificities; it was presumably specific for the a1-D allotypic subspecificity. The a1-AB Ig subpopulation escaped from allotype suppression in rabbit P286-3, whereas the a1-AC and a1-AD Ig subpopulations remained suppressed. The a1-AD Ig subpopulation will probably remain suppressed for a long time, perhaps permanently, since rabbit P286-3 has produced circulating auto-Ab specific for the a1-D allotypic subspecificity. The a1 Ig subpopulations are apparently synthesized by distinct clones of lymphocytes under separate control.

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