HISTOCHEMICAL AND ULTRASTRUCTURAL-STUDY OF LACTIC-DEHYDROGENASE IN CHEMICALLY-INDUCED LUNG-CANCER

  • 1 January 1978
    • journal article
    • research article
    • Vol. 38  (9) , 2790-2794
Abstract
Light microscopy and EM studies of lactic dehydrogenase activity were done in embryonic, neonatal and adult mouse lungs and lungs undergoing chemically induced carcinogenesis. Embryonic mouse lungs were collected on the 6th, 12th and 18th days of gestation; 1-day-old lungs were used for the neonatal model. These were compared with adult normal mouse lung and lungs of animals treated with 4-nitroquinoline-1-oxide at a monthly interval until cancer developed. Enzymatic activity was seen in the embryonic, precancerous and malignant lung tissues and was found diffusely in the cytoplasm of epithelial cells.

This publication has 1 reference indexed in Scilit: