Calcium Channels--Link Locally, Act Globally
- 12 October 2001
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 294 (5541) , 318-319
- https://doi.org/10.1126/science.1066160
Abstract
Ca-dependent gene transcription and L-type Cachannel inactivation share a common initiating event. As Ikeda explains in his Perspective, in each case, local increases in [Ca] result in binding to calmodulin that is tethered to the Cachannel protein. An accompanying conformational change triggers phosphorylation of the transcription factor CREB and closure, or inactivation, of L-type Cachannels ( Dolmetsch et al.).Keywords
This publication has 19 references indexed in Scilit:
- Signaling to the Nucleus by an L-type Calcium Channel-Calmodulin Complex Through the MAP Kinase PathwayScience, 2001
- Molecular Basis of Calmodulin Tethering and Ca2+-dependent Inactivation of L-type Ca2+ ChannelsJournal of Biological Chemistry, 2001
- Calmodulin bifurcates the local Ca2+ signal that modulates P/Q-type Ca2+ channelsNature, 2001
- The Sequence of the Human GenomeScience, 2001
- Calmodulin Is the Ca2+ Sensor for Ca2+-Dependent Inactivation of L-Type Calcium ChannelsNeuron, 1999
- Ca 2+ -sensitive inactivation of L-type Ca 2+ channels depends on multiple cytoplasmic amino acid sequences of the α 1C subunitProceedings of the National Academy of Sciences, 1998
- Signaling from Synapse to Nucleus: Postsynaptic CREB Phosphorylation during Multiple Forms of Hippocampal Synaptic PlasticityNeuron, 1996
- CREB: a Ca 2+ -Regulated Transcription Factor Phosphorylated by Calmodulin-Dependent KinasesScience, 1991
- Dominant Role of N-Type Ca 2+ Channels in Evoked Release of Norepinephrine from Sympathetic NeuronsScience, 1988
- Calcium Entry Leads to Inactivation of Calcium Channel in ParameciumScience, 1978