Interferon alfa-2b in mixed cryoglobulinaemia: a controlled crossover trial.
Open Access
- 1 January 1993
- Vol. 34 (2 Suppl) , S144-S145
- https://doi.org/10.1136/gut.34.2_suppl.s144
Abstract
To confirm the positive results of a preliminary trial, 26 patients with mixed cryoglobulinaemia were enrolled in a controlled, randomised, crossover trial with interferon alfa-2b. A significant improvement was seen in the purpura score and alanine aminotransferase activities during six months' treatment, and was associated with a significant decrease in cryocrit and a returning to normal of the lymphocyte CD4/CD8 ratio (in eight of nine patients). No significant variations were seen during the six month period without interferon. Only six patients withdrew from treatment, three because of side effects and three because of poor compliance.Keywords
This publication has 8 references indexed in Scilit:
- Alpha interferon in the treatment of mixed cryoglobulinaemia patientsEuropean Journal of Cancer and Clinical Oncology, 1991
- Long-term results of therapy with interferon-alpha for type II essential mixed cryoglobulinemia.1991
- Antibodies to hepatitis C virus in patients with mixed cryoglobulinemiaArthritis & Rheumatism, 1991
- Association between hepatitis C virus and mixed cryoglobulinemia [see comment].1991
- Antibodies against hepatitis C virus in mixed cryoglobulinemia patientsInfection, 1991
- Low-antigen-content diet in the treatment of patients with mixed cryoglobulinemiaThe American Journal of Medicine, 1989
- Plasma-exchange in mixed cryoglobulinemia. Effects on renal, liver and neurologic involvementLa Ricerca in Clinica e in Laboratorio, 1986
- Treatment of the Renal Involvement in Mixed Cryoglobulinemia with Prolonged Plasma ExchangeNephron, 1986