Bile acid metabolism in ileostomy patients

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Abstract
In 10 ileostomy patients a 14C-cholylglycine breath test was performed. The 14CO2 in the exhaled air the 14C bile acid quantity and composition, and the fat content in the subsequent 24 h ileostomy effluent were determined and compared to the values in 20 healthy controls. In ileostomy patients only minor bile acid-deconjugation occurs in vivo. Deconjugation in the ileostomy bags was mainly responsible for the absence of conjugated bile acids in many of the ileostomy effluent samples. Secondary bile acids were not present in these patients, as determined by TLC. The fecal fat and bile acid excretion was found to be in the normal range in ileostomy patients, provided no concomitant ileum resection was present.